Analysis of expression of luteal genes during induced luteolysis and rescue of luteal function in bonnet macaques and Pregnant Rats

Analysis of expression of luteal genes during induced luteolysis and rescue of luteal function in bonnet macaques and Pregnant Rats

Studies have been carried out to standardize induced luteolysis model systems ƵƟůŝnjŝnŐ female monkeys and pregnant rats. In monkeys, ĂĚmŝnŝƐƚrĂƟŽn of a single ŝnũĞcƟŽn of GnRH receptor antagonist, Cetrorelix (CET; 150 µg/kg BW s.c.,), on day 7 of the luteal phase led to profound decrease in serum progesterone (P4) cŽncĞnƚrĂƟŽn within 24 h (3.6 ± 1.1 vs 0.8 ± 0.2 ng/ml before and 24 h post CET, rĞƐƉĞcƟvĞůy p<0.05), and followed by the premature onset of menses 96 h later.

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